Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 6/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24449110 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL19307174 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL29614895 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL2628778 | 0.78 | TRPM8 (0.52) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL2243144 | 0.77 | ALDH1A1 (0.76) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL2628682 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL2628776 | 0.75 | MAPT (0.56) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL29000625 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL2244900 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDRAB9A | |
| SCHEMBL19307177 | 0.72 | ALDH1A1 (0.74) | KDM4EALDH1A1HSD17B10HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389730-B2 | Compositions and methods for the treatment of disease associated with TRP-P8 expression | DENDREON CORPORATION (US) | 2013-03-05 | — | — | US | disclosed |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | TRPC4, TRPC3, TRPC1 | KDM4E 4239/4885ALDH1A1 4742/4885HSD17B10 3871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.