Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.42 |
| ▸ | MET | P08581 | 6/20 | 0.42 |
| ▸ | EP300 | Q09472 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26294392 | 1.00 | AXL (0.45) | AXLMERTKMAPK1METEP300 | |
| SCHEMBL26294429 | 0.90 | MAPK1 (0.42) | AXLMERTKMAPK1METKDM4E | |
| SCHEMBL26294378 | 0.89 | MAPK1 (0.43) | AXLMERTKMAPK1METGSK3B | |
| SCHEMBL26294091 | 0.88 | MAPK1 (0.42) | AXLMERTKMAPK1METEP300 | |
| SCHEMBL26294072 | 0.88 | MAPK1 (0.42) | AXLMERTKMAPK1METEP300 | |
| SCHEMBL25405675 | 0.83 | AXL (0.42) | AXLMERTKMAPK1METGSK3B | |
| SCHEMBL25404507 | 0.83 | AXL (0.42) | AXLMERTKMAPK1METGSK3B | |
| SCHEMBL25404502 | 0.83 | AXL (0.42) | AXLMERTKMAPK1METGSK3B | |
| SCHEMBL26276721 | 0.82 | MAP4K4 (0.42) | MAPK1GSK3BDYRK1A | |
| SCHEMBL25406685 | 0.80 | SCN9A (0.42) | AXLMERTKMAPK1METEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295152-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | SENDA BIOSCIENCES, INC. (US) | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295152-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | AHR, ARNT, AIPL1 | AXL 1370/4885MERTK 648/4885MAPK1 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.