Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | GGT1 | P19440 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720572 | 0.84 | KDM4E (0.55) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL28749550 | 0.83 | PTGS2 (0.50) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| Hydrogen Peroxide SCHEMBL8008634 | 0.82 | KDM4E (0.58) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL8324534 | 0.82 | PTGS2 (0.53) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL11606741 | 0.82 | PTGS2 (0.57) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL6054582 | 0.81 | P2RX3 (0.42) | ALDH1A1MAPK1ACHEHTT | |
| SCHEMBL27643582 | 0.81 | KDM4E (0.48) | PTGS2KDM4ELMNAMEN1KMT2A | |
| SCHEMBL6250169 | 0.81 | PTGS2 (0.52) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL28550170 | 0.80 | PTGS2 (0.47) | PTGS2KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL18499347 | 0.80 | PTGS2 (0.55) | PTGS2KDM4EHSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107573360-A | A kind of Mutiple Targets micromolecular compound S63845 preparation method | 都创(上海)医药科技有限公司 | 2018-01-12 | — | — | CN | claimed |
| US-11091484-B2 | Tricyclic heterocycles as BET protein inhibitors | INCYTE CORPORATION (US) | 2021-08-17 | — | — | US | disclosed |
| US-10442803-B2 | Tricyclic heterocycles as bet protein inhibitors | INCYTE CORPORATION (US) | 2019-10-15 | — | — | US | disclosed |
| CN-107573360-A | A kind of Mutiple Targets micromolecular compound S63845 preparation method | 都创(上海)医药科技有限公司 | 2018-01-12 | — | — | CN | disclosed |
| US-20180002334-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION | 2018-01-04 | — | — | US | disclosed |
| EP-2443485-B1 | BIOMEDICAL DEVICES | BAUSCH & LOMB (US) | 2017-11-08 | — | — | EP | disclosed |
| US-9777003-B2 | Tricyclic heterocycles as bet protein inhibitors | INCYTE CORPORATION (US) | 2017-10-03 | — | — | US | disclosed |
| EP-2443486-B1 | BIOMEDICAL DEVICES | BAUSCH & LOMB (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2443482-B1 | BIOMEDICAL DEVICES, POLYMERIC MATERIALS AND CONTACT LENSES COMPRISING THE SAME. | BAUSCH & LOMB (US) | 2017-03-01 | — | — | EP | disclosed |
| US-20160168148-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION | 2016-06-16 | — | — | US | disclosed |
| US-9309246-B2 | Tricyclic heterocycles as BET protein inhibitors | INCYTE CORPORATION (US) | 2016-04-12 | — | — | US | disclosed |
| WO-2015095492-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION (US) | 2015-06-25 | — | — | WO | disclosed |
| US-20150175604-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION (US) | 2015-06-25 | — | — | US | disclosed |
| US-8133960-B2 | Biomedical devices | BAUSCH & LOMB INCORPORATED (US) | 2012-03-13 | — | — | US | disclosed |
| US-8083348-B2 | Biomedical devices | BAUSCH & LOMB INCORPORATED (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100317816-A1 | Biomedical devices | BAUSCH & LOMB INCORPORATED (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317817-A1 | Biomedical devices | BAUSCH & LOMB INCORPORATED (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100315588-A1 | Biomedical devices | BAUSCH & LOMB INCORPORATED (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002334-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | BRD1, BRD3, BRD2 | PTGS2 2814/4885KDM4E 1807/4885HSD17B10 2099/4885 |
| US-10442803-B2 | Tricyclic heterocycles as bet protein inhibitors | BRD1, BRD3, BRD2 | PTGS2 2814/4885KDM4E 1807/4885HSD17B10 2099/4885 |
| US-20160168148-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | BRD1, BRD3, BRD2 | PTGS2 2814/4885KDM4E 1807/4885HSD17B10 2099/4885 |
| US-11091484-B2 | Tricyclic heterocycles as BET protein inhibitors | BRD1, BRD3, BRD2 | PTGS2 2814/4885KDM4E 1807/4885HSD17B10 2099/4885 |
| US-20150175604-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | BRD1, BRD3, BRD2 | PTGS2 2814/4885KDM4E 1807/4885HSD17B10 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.