Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.40 |
| ▸ | SHBG | P04278 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.34 |
| ▸ | SNCA | P37840 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16842370 | 1.00 | NR3C1 (0.40) | NR3C1SHBGHSD17B10ARPGR | |
| SCHEMBL2618325 | 1.00 | NR3C1 (0.40) | NR3C1SHBGHSD17B10ARPGR | |
| SCHEMBL1880354 | 0.90 | NR3C1 (0.41) | NR3C1SHBGHSD17B10ARPGR | |
| SCHEMBL11636367 | 0.90 | NR3C1 (0.41) | NR3C1SHBGHSD17B10ARPGR | |
| SCHEMBL267390 | 0.90 | NR3C1 (0.41) | NR3C1SHBGHSD17B10ARPGR | |
| SCHEMBL17547203 | 0.87 | NR3C1 (0.39) | NR3C1SHBGHSD17B10ARPGR | |
| SCHEMBL12654408 | 0.79 | NR3C1 (0.40) | NR3C1ARCYP19A1 | |
| SCHEMBL2631296 | 0.74 | NR3C1 (0.35) | NR3C1 | |
| SCHEMBL2618320 | 0.74 | CYP19A1 (0.44) | NR3C1CYP19A1 | |
| SCHEMBL13476641 | 0.71 | NR3C1 (0.47) | NR3C1SHBGHSD17B10ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338472-B2 | Hexahydrocyclopentyl[F]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8299048-B2 | Hexahydrocyclopentyl[f]indazole sulfonamides and derivatives thereof as selective glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120214846-A1 | HEXAHYDROCYCLOPENTYL[F]INDAZOLE PYRIDYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP (US) | 2012-08-23 | — | — | US | disclosed |
| EP-2265273-B1 | HEXAHYDROCYCLOPENTYL[F] INDAZOLE SULFONAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120172397-A1 | HEXAHYDROCYCLOPENTA[f]INDAZOLE 5-YL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-07-05 | — | — | US | disclosed |
| US-20120095055-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE 5-HYDROXYMETHYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME, CORP. (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2011053567-A1 | HEXAHYDROCYCLOPENTYL[F]INDAZOLE PYRIDYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-05-05 | — | — | WO | disclosed |
| US-20110105440-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE SULFONAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. | 2011-05-05 | — | — | US | disclosed |
| US-20110003797-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE CARBOXAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. | 2011-01-06 | — | — | US | disclosed |
| WO-2010141247-A1 | HEXAHYDROCYCLOPENTYL[∫]INDAZOLE 5-HYDROXYMETHYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010138421-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE REVERSED AMIDES AND DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2009111214-A1 | HEXAHYDROCYCLOPENTYL[F]INDAZOLE SULFONAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009108525-A2 | HEXAHYDROCYCLOPENTYL[F]INDAZOLE CARBOXAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| US-20090143346-A1 | Method for synthesizing furanosteroids | TRUSTEES OF DARTMOUTH COLLEGE | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095055-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE 5-HYDROXYMETHYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885SHBG 248/4885HSD17B10 627/4885 |
| US-20110003797-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE CARBOXAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885SHBG 313/4885HSD17B10 1539/4885 |
| US-20110105440-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE SULFONAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885SHBG 195/4885HSD17B10 1520/4885 |
| US-20090143346-A1 | Method for synthesizing furanosteroids | HSD17B7, HSD17B13, CYP17A1 | NR3C1 58/4885SHBG 148/4885HSD17B10 56/4885 |
| US-20120214846-A1 | HEXAHYDROCYCLOPENTYL[F]INDAZOLE PYRIDYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885SHBG 254/4885HSD17B10 851/4885 |
| US-20120172397-A1 | HEXAHYDROCYCLOPENTA[f]INDAZOLE 5-YL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885SHBG 347/4885HSD17B10 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.