Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.45 |
| ▸ | CHRNG | P07510 | 1/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRND | Q07001 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12384333 | 1.00 | GRIA1 (0.48) | GRIA1FOLH1PTPN1CHRNA1CHRNG | |
| SCHEMBL21881743 | 0.90 | FOLH1 (0.50) | GRIA1FOLH1PTPN1CHRNA1CHRNG | |
| SCHEMBL2631415 | 0.84 | HDAC3 (0.42) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL12384334 | 0.84 | HDAC3 (0.42) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2099399 | 0.79 | NPSR1 (0.56) | PTPN1 | |
| SCHEMBL2099396 | 0.79 | NPSR1 (0.56) | PTPN1 | |
| SCHEMBL14761090 | 0.74 | CHRNB2 (0.63) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL14761872 | 0.74 | CHRNB2 (0.63) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL14761840 | 0.74 | CHRNB2 (0.63) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL14761539 | 0.74 | CHRNB2 (0.63) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476661-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2009-01-13 | — | — | US | disclosed |