Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAT2A | P31153 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24108945 | 0.87 | POLB (0.56) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8123477 | 0.86 | MAT2A (0.57) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22750952 | 0.82 | KDM4E (0.66) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13585102 | 0.82 | KDM4E (0.62) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13726180 | 0.82 | KDM4E (0.52) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11807689 | 0.80 | KDM4E (0.59) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13585117 | 0.80 | KDM4E (0.58) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13726642 | 0.77 | MAPT (0.58) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL24108915 | 0.76 | DHODH (0.58) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL24108905 | 0.76 | KDM4E (0.63) | KDM4EMAPK1MAT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257359-A1 | 4-ARYLQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257359-A1 | 4-ARYLQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | MAT2A, MAT2B, MAT1A | KDM4E 811/4885MAPK1 3180/4885MAT2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.