Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26194442 | 0.93 | LMNA (0.39) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL17558512 | 0.92 | KDM4E (0.39) | HCAR3KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL26314548 | 0.92 | KDM4E (0.39) | HCAR3KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17565611 | 0.90 | KDM4E (0.36) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL26314543 | 0.85 | ALDH1A1 (0.39) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL18468871 | 0.83 | ALDH1A1 (0.38) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL26314541 | 0.83 | KMT2A (0.40) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL17542198 | 0.82 | KDM4E (0.36) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL29436682 | 0.82 | KDM4E (0.36) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL17542342 | 0.82 | KDM4E (0.36) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | MCL1, BAK1, BCL3 | HCAR3 4848/4885KDM4E 1483/4885SMN1; SMN2 1917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.