Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26323371 | 0.82 | CBFB (0.36) | NPC1RAB9APKMCHEK2ACHE | |
| SCHEMBL18365245 | 0.72 | NPC1 (0.68) | NPC1RAB9APKMCHEK2ACHE | |
| SCHEMBL24075318 | 0.68 | RAB9A (0.66) | NPC1RAB9APKMKDM4EALDH1A1 | |
| SCHEMBL13243547 | 0.67 | NPC1 (0.64) | NPC1RAB9APKMKDM4EALDH1A1 | |
| SCHEMBL3335441 | 0.67 | NPC1 (1.00) | NPC1RAB9APKMKDM4EALDH1A1 | |
| SCHEMBL18365234 | 0.66 | NPC1 (0.59) | NPC1RAB9APKMCHEK2KDM4E | |
| SCHEMBL13533785 | 0.66 | NPC1 (0.62) | NPC1RAB9APKMKDM4EALDH1A1 | |
| SCHEMBL18375988 | 0.66 | NPC1 (0.57) | NPC1RAB9APKMCHEK2KDM4E | |
| SCHEMBL26323330 | 0.64 | KDR (0.42) | NPC1RAB9ACHEK2KDM4EALDH1A1 | |
| SCHEMBL9306624 | 0.63 | HPSE (0.52) | NPC1RAB9APKMCHEK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | NPC1 1106/4885RAB9A 1430/4885PKM 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.