Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306635 | 0.88 | HPSE (0.64) | HPSECHEK2DGAT1KCNH2CHEK1 | |
| SCHEMBL415254 | 0.85 | CHEK1 (0.55) | CHEK2GUSBDGAT1KCNH2CHEK1 | |
| SCHEMBL5579984 | 0.85 | CHEK1 (0.59) | CHEK2GUSBDGAT1KCNH2CHEK1 | |
| SCHEMBL24295302 | 0.81 | CHEK2 (0.57) | HPSECHEK2KDM4ENPC1ALDH1A1 | |
| SCHEMBL5579690 | 0.81 | CHEK2 (0.59) | CHEK2KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL465476 | 0.80 | PLG (0.56) | CHEK2 | |
| SCHEMBL21018202 | 0.80 | HPSE (0.55) | HPSECHEK2NPBWR1 | |
| SCHEMBL21018203 | 0.80 | CHEK2 (0.67) | HPSECHEK2DGAT1KCNH2KDM4E | |
| SCHEMBL7388566 | 0.79 | GUSB (0.57) | HPSECHEK2GUSBDGAT1KCNH2 | |
| SCHEMBL7394693 | 0.79 | KDM4E (0.54) | CHEK2GUSBDGAT1KCNH2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5317078-A | Lower glass transition temperature and improved solvent solubility of polyether molding materials of macrocyclic monomers polymerized using an alkali basic catalyst and solvent; films | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1994-05-31 | — | — | US | disclosed |
| US-5245044-A | Di(hydroxyphenyl)-benzimidazole monomers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1993-09-14 | — | — | US | disclosed |