Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 14/20 | 0.65 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.65 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.65 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.65 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.34 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263291 | 0.90 | SCN10A (0.79) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263316 | 0.89 | SCN10A (0.81) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263869 | 0.87 | SCN10A (0.52) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL3081825 | 0.87 | SCN10A (0.51) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237357 | 0.86 | SCN10A (0.58) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263374 | 0.80 | SCN10A (0.64) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263206 | 0.79 | SCN10A (0.77) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237456 | 0.79 | SCN10A (0.76) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237596 | 0.79 | SCN10A (0.65) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL262780 | 0.79 | SCN10A (1.00) | SCN10ASCN9ASCN5ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |
| US-8134007-B2 | Pyridine derivatives | PFIZER INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20090048306-A1 | PYRIDINE DERIVATIVES | PFIZER, INC. (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048306-A1 | PYRIDINE DERIVATIVES | SDHA, P2RX4, P2RX3 | SCN10A 358/4885SCN9A 491/4885SCN5A 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.