Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NME4 | O00746 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24346426 | 0.85 | HTT (0.46) | HPGDRAB9ASMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL23015946 | 0.83 | ESRRG (0.37) | RAB9ANPC1SMN1; SMN2KMT2AHTT | |
| SCHEMBL21307589 | 0.80 | ESRRG (0.36) | SMN1; SMN2L3MBTL1HTTMAPTTP53 | |
| SCHEMBL21307471 | 0.80 | ESRRG (0.35) | SMN1; SMN2L3MBTL1HTTNME4ADORA3 | |
| SCHEMBL21307568 | 0.80 | HTT (0.38) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL23015947 | 0.80 | HPGD (0.38) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL21307569 | 0.79 | MAP4K1 (0.35) | RAB9ANPC1KMT2AHTTMEN1 | |
| SCHEMBL17320175 | 0.79 | CA1 (0.52) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL21307560 | 0.78 | ESRRG (0.40) | HPGDRAB9ANPC1HTTNME4 | |
| SCHEMBL23561922 | 0.78 | ESRRG (0.35) | HPGDSMN1; SMN2KMT2AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | TAB1, CHUK, TGFBR1 | HPGD 3093/4885RAB9A 3987/4885NPC1 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.