Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222514 | 1.00 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL12810140 | 1.00 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL5222510 | 1.00 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL5222520 | 1.00 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL5224782 | 0.97 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL5224778 | 0.97 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL5224786 | 0.97 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL8744470 | 0.93 | CYP2D6 (0.60) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL8744474 | 0.93 | CYP2D6 (0.60) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL8744478 | 0.93 | CYP2D6 (0.60) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163938-B2 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2012-04-24 | — | — | US | disclosed |
| US-20110004006-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110004006-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | KCNH2, KCNC1, KCNH3 | CYP2D6 58/4885CYP1A2 115/4885CYP3A4 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.