Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2524154 | 0.85 | L3MBTL1 (0.52) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL24754816 | 0.84 | TRPV3 (0.57) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL226611 | 0.84 | TRPV3 (0.51) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL30931690 | 0.83 | TRPV3 (0.52) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL7840899 | 0.83 | TRPV3 (0.59) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL23121539 | 0.83 | TRPV3 (0.52) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL7832327 | 0.83 | TRPV3 (0.52) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL17459263 | 0.80 | MAOB (0.53) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL31375611 | 0.80 | MAOB (0.53) | TRPV3L3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL91372 | 0.80 | MAOB (0.43) | TRPV3MAPK1MAPTHTTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |