Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.53 |
| ▸ | MTOR | P42345 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187949 | 0.83 | ALDH1A1 (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15065230 | 0.83 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14300937 | 0.81 | PIK3CA (0.50) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14306585 | 0.81 | METAP2 (0.37) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL6128039 | 0.75 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1897045 | 0.75 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL6128040 | 0.74 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL188527 | 0.73 | WEE1 (0.44) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL1898472 | 0.72 | PIK3CA (0.65) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1897638 | 0.72 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-B9 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2056829-B1 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-01-04 | — | — | EP | disclosed |