Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.73 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.73 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | CDC42 | P60953 | 1/20 | 0.73 |
| ▸ | RAC1 | P63000 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478228 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL30380801 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL9119592 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL30760568 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL5906550 | 0.86 | AKR1C3 (0.88) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL42434 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL616149 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL20887114 | 0.85 | PTGS2 (0.81) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL215236 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL5534049 | 0.85 | PTGS2 (0.81) | PTGS2AKR1C3AKR1C2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1867572-A | proteasome inhibitors and methods of use thereof | CEPHALON INC (US) | 2006-11-22 | — | — | CN | claimed |
| EP-0549710-B1 | A PROCESS FOR THE PREPARATION OF ENANTIOMERIC 2-ALKANOIC ACIDS | DU PONT (US) | 1996-02-28 | — | — | EP | claimed |
| EP-0549710-A1 | A PROCESS FOR THE PREPARATION OF ENANTIOMERIC 2-ALKANOIC ACIDS. | DU PONT (US) | 1993-07-07 | — | — | EP | claimed |
| EP-0537259-A1 | PROCESS FOR PRODUCING ENANTIOMERS OF 2-ARYL-ALKANOIC ACIDS | NOVO NORDISK A/S (DK) | 1993-04-21 | — | — | EP | claimed |
| WO-1992005275-A1 | A PROCESS FOR THE PREPARATION OF ENANTIOMERIC 2-ALKANOIC ACIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-02 | — | — | WO | claimed |
| WO-1992001062-A1 | PROCESS FOR PRODUCING ENANTIOMERS OF 2-ARYL-ALKANOIC ACIDS | NOVO NORDISK A/S (DK) | 1992-01-23 | — | — | WO | claimed |
| EP-0386848-A1 | Novel Exophiala species | GIST-BROCADES N.V. (NL) | 1990-09-12 | — | — | EP | claimed |
| US-4347373-A | Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole | TURCONI FRANCO | 1982-08-31 | — | — | US | claimed |
| US-3978124-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | claimed |
| CN-112299938-B | Method for preparing amine compound by reducing amide compound | 中国科学院兰州化学物理研究所 | 2021-12-28 | — | — | CN | disclosed |
| CN-112299938-A | Method for preparing amine compound by reducing amide compound | 中国科学院兰州化学物理研究所 | 2021-02-02 | — | — | CN | disclosed |
| EP-1913011-B1 | OLIGONUCLEOTIDES COMPRISING A LIGAND TETHERED TO A MODIFIED OR NON-NATURAL NUCLEOBASE | ALNYLAM PHARMACEUTICALS INC (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-1789553-B1 | OLIGONUCLEOTIDES COMPRISING A NON-PHOSPHATE BACKBONE LINKAGE | ALNYLAM PHARMACEUTICALS INC (US) | 2014-03-26 | — | — | EP | disclosed |
| US-8470988-B2 | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety | ALNYLAM PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| EP-0385692-A2 | Optcally active compounds | SANYO CHEMICAL INDUSTRIES LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |
| EP-0205215-B1 | PROCESS FOR THE PREPARATION OF 2-ARYLPROPIONIC ACIDS | GIST-BROCADES N.V. (NL) | 1990-08-08 | — | — | EP | disclosed |
| EP-0182279-B1 | PROCESS FOR THE OPTICAL RESOLUTION OF RACEMIC MIXTURES OF ALPHA-NAPHTYL-PROPIONIC ACIDS | ALFA WASSERMANN S.p.A. (IT) | 1990-02-28 | — | — | EP | disclosed |
| EP-0205215-A2 | Process for the preparation of 2-arylpropionic acids | GIST-BROCADES N.V. (NL) | 1986-12-17 | — | — | EP | disclosed |
| US-4327022-A | Heterocyclic alkyl naphthols | STERLING DRUG INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4169108-A | 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols | STERLING DRUG INC. (US) | 1979-09-25 | — | — | US | disclosed |