Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.73 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.73 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | CDC42 | P60953 | 1/20 | 0.73 |
| ▸ | RAC1 | P63000 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478228 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL30380801 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL263373 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL30760568 | 1.00 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL5906550 | 0.86 | AKR1C3 (0.88) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL42434 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL616149 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL20887114 | 0.85 | PTGS2 (0.81) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL215236 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| Naproxen SCHEMBL10029028 | 0.85 | AKR1C3 (1.00) | PTGS2AKR1C3AKR1C2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398288-B1 | Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids | PUETTER MEDICE CHEM PHARM (DE) | 1995-10-18 | — | — | EP | disclosed |
| US-5380927-A | Process for preparing optically active 2-aryl-alkanoic acids, in particular 2-aryl-propionic acids | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1995-01-10 | — | — | US | disclosed |
| US-5266723-A | Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids | MEDICE, LTD., CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1993-11-30 | — | — | US | disclosed |
| EP-0398288-A2 | Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
| EP-0205215-B1 | PROCESS FOR THE PREPARATION OF 2-ARYLPROPIONIC ACIDS | GIST-BROCADES N.V. (NL) | 1990-08-08 | — | — | EP | disclosed |
| EP-0205215-A2 | Process for the preparation of 2-arylpropionic acids | GIST-BROCADES N.V. (NL) | 1986-12-17 | — | — | EP | disclosed |