Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 17/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 17/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 17/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 17/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.58 |
| ▸ | CHRNA1 | P02708 | 16/20 | 0.58 |
| ▸ | CHRNB1 | P11230 | 16/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.58 |
| ▸ | CHRNG | P07510 | 15/20 | 0.58 |
| ▸ | CHRND | Q07001 | 15/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Manifaxine SCHEMBL2954001 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL7775056 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL4650329 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL9696551 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL1820725 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL9696258 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL9696265 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL9695101 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL9697408 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 | |
| Manifaxine SCHEMBL9696223 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536717-B1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-06-04 | — | — | EP | disclosed |
| EP-2536716-B1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-21 | — | — | EP | disclosed |
| EP-2536717-A1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-12-26 | — | — | EP | disclosed |
| EP-2536716-A1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-12-26 | — | — | EP | disclosed |
| EP-2513096-A1 | SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-A MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2132188-B1 | SUBSTITUTED PHENOXY N-ALKYLATED THIAZOLEDINEDIONE AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2011149841-A1 | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-α MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-01 | — | — | WO | disclosed |
| EP-2134698-A1 | SUBSTITUTED PHENOXY AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2009-12-23 | — | — | EP | disclosed |
| EP-2132188-A2 | SUBSTITUTED PHENOXY N-ALKYLATED THIAZOLEDINEDIONE AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2009-12-16 | — | — | EP | disclosed |
| EP-2129668-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008109727-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008109737-A1 | SUBSTITUTED PHENOXY AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008109731-A2 | SUBSTITUTED PHENOXY N-ALKYLATED THIAZOLEDINEDIONE AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JASSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |