Manifaxine

Manifaxine

SCHEMBL4650329

CC1COC(O)(c2cc(F)cc(F)c2)C(C)N1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 17/20 0.58
CHRNB4 P30926 17/20 0.58
CHRNA3 P32297 17/20 0.58
CHRNA4 P43681 17/20 0.58
SLC6A2 P23975 16/20 0.58
CHRNA1 P02708 16/20 0.58
CHRNB1 P11230 16/20 0.58
SLC6A3 Q01959 15/20 0.58
CHRNG P07510 15/20 0.58
CHRND Q07001 15/20 0.58
SLC6A4 P31645 5/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Manifaxine SCHEMBL2954001 1.00 CHRNB2 (0.58) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL7775056 1.00 CHRNB2 (0.58) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL2633826 1.00 CHRNB2 (0.58) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL9696551 1.00 CHRNB2 (0.58) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL1820725 0.98 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL9696258 0.98 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL9696265 0.98 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL9695101 0.98 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL9697408 0.98 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2
Manifaxine SCHEMBL9696223 0.98 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5104870-A Psychological disorders BURROUGHS WELLCOME CO. (US) 1992-04-14 US claimed
EP-0426416-A1 Novel morpholinol compounds, their preparation and use THE WELLCOME FOUNDATION LIMITED (GB) 1991-05-08 EP claimed
EP-1968603-A2 THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS Algebra Inc. (US) 2008-09-17 EP disclosed
WO-2007079470-A2 THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS ALGEBRA, INC. (US) 2007-07-12 WO disclosed
EP-1117407-A1 ORAL DOSAGE FORMULATIONS COMPRISING (2S, 3S,5R)-2-(3,5-DIFLUOROPHENYL) -3,5-DIMETHYL-2-MORPHOLINOL AND AN EFFECTIVE STABILIZING AMOUNT OF ALGINIC ACID GLAXO GROUP LIMITED (GB) 2001-07-25 EP disclosed