Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422069 | 0.84 | KDM4E (0.52) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL26351545 | 0.80 | KDM4E (0.36) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL14037715 | 0.80 | KDM4E (0.40) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL3279759 | 0.77 | KDM4E (0.42) | KDM4EBAZ2BALDH1A1LMNAADORA2A | |
| SCHEMBL21767220 | 0.77 | BCHE (0.35) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL21784450 | 0.77 | BCHE (0.35) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL26342519 | 0.77 | BAZ2B (0.32) | BAZ2B | |
| SCHEMBL16642354 | 0.74 | BAZ2B (0.35) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL25242267 | 0.74 | KDM4E (0.36) | KDM4EGRNSORT1BAZ2BBCHE | |
| SCHEMBL26362005 | 0.74 | ADORA2A (0.37) | KDM4EGRNSORT1BAZ2BBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | KDM4E 2919/4885GRN 2987/4885SORT1 4649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.