Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26344212 | 0.90 | PDE9A (0.43) | PDE2AOPRM1 | |
| SCHEMBL26344183 | 0.85 | PDE2A (0.41) | PDE2ACHRM2CHRM4CHRM1CHRM5 | |
| SCHEMBL29588826 | 0.80 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| SCHEMBL26662006 | 0.80 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| SCHEMBL26344207 | 0.80 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| Calcium SCHEMBL30637044 | 0.80 | CHRM2 (0.42) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| SCHEMBL30637047 | 0.80 | CHRM2 (0.42) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| Diethylamine SCHEMBL30637040 | 0.78 | CHRM2 (0.39) | PDE2ACHRM2CHRM4CHRM1CHRM5 | |
| SCHEMBL26344164 | 0.76 | MEN1 (0.39) | PDE2A | |
| SCHEMBL30459661 | 0.71 | PDE9A (0.39) | PDE2AOPRM1PDE1BOPRL1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4249474-A1 | TRIAZINE DIONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-09-27 | — | — | EP | disclosed |