Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RNF4 | P78317 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GPX4 | P36969 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901552 | 0.87 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1GLAGAAPOLB | |
| SCHEMBL20169531 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1GLAGAAPOLB | |
| SCHEMBL6382412 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9APAX8JAK2 | |
| SCHEMBL8858955 | 0.86 | ALDH1A1 (0.57) | SMN1; SMN2NPC1RAB9APAX8JAK2 | |
| SCHEMBL4434199 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1GLAGAAPOLB | |
| SCHEMBL5807041 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1GLAGAAPOLB | |
| SCHEMBL28970973 | 0.84 | RNF4 (0.55) | SMN1; SMN2NPC1RAB9AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL4434198 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GLAGAAPOLB | |
| SCHEMBL7174025 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GLAGAAPOLB | |
| SCHEMBL9366543 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GLAGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115838355-B | 1, 4-Disubstituted piperazine-2, 5-dione derivative, preparation method and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2024-12-03 | — | — | CN | disclosed |
| CN-115838355-A | 1, 4-disubstituted piperazine-2, 5-diketone derivative, preparation method and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-03-24 | — | — | CN | disclosed |
| US-20120220577-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO KGAA | 2012-08-30 | — | — | US | disclosed |
| EP-2438037-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139481-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |
| US-4385922-A | Method of increasing the yield of legumes utilizing D- or DL-α-O,O-diethlyphosphorodithioylacetylphenylglycine ethyl esters | STAUFFER CHEMICAL COMPANY (US) | 1983-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220577-A1 | GLYCINE B ANTAGONISTS | GLRB, GRIN2B, GLRA2 | SMN1; SMN2 508/4885NPC1 215/4885RAB9A 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.