Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171433 | 0.86 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL4171436 | 0.86 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL4170455 | 0.86 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL14248546 | 0.83 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263552 | 0.83 | KMT2A (0.45) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL262802 | 0.80 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL262926 | 0.80 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263553 | 0.79 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL263135 | 0.79 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL9277340 | 0.79 | GAA (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |