Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412194 | 0.85 | KMT2A (0.59) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL434556 | 0.85 | KMT2A (0.59) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL11847525 | 0.83 | MAPT (0.58) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL31112176 | 0.83 | MAPT (0.58) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL6966397 | 0.82 | KMT2A (0.56) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL31112550 | 0.81 | KMT2A (0.54) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL3760693 | 0.81 | NPSR1 (0.58) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| Lithium Ion SCHEMBL11844852 | 0.79 | KMT2A (0.53) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL26356315 | 0.79 | KMT2A (0.49) | KMT2AMAPTSMN1; SMN2SLC6A3NPSR1 | |
| SCHEMBL4479762 | 0.78 | KMT2A (0.54) | KMT2AMAPTSMN1; SMN2NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303599-A1 | PRODRUGS OF PHOSPHONAMIDE NUCLEOTIDE ANALOGUES AND THEIR PHARMACEUTICAL USE | GILEAD SCIENCES, INC. | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303599-A1 | PRODRUGS OF PHOSPHONAMIDE NUCLEOTIDE ANALOGUES AND THEIR PHARMACEUTICAL USE | PNP, TYMP, NME2 | KMT2A 4151/4885MAPT 3579/4885SMN1; SMN2 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.