Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.49 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636695 | 1.00 | HSD11B1 (0.53) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL2636353 | 0.88 | HSD11B1 (0.58) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL12847410 | 0.88 | HSD11B1 (0.58) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL2636354 | 0.88 | HSD11B1 (0.58) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL2636352 | 0.88 | HSD11B1 (0.58) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL2636625 | 0.87 | HSD11B1 (0.56) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL2636623 | 0.87 | HSD11B1 (0.56) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL12847409 | 0.81 | HSD11B1 (0.58) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL12792023 | 0.80 | HSD11B1 (0.55) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 | |
| SCHEMBL12791971 | 0.79 | HSD11B1 (0.54) | HSD11B1CYP3A4CYP2D6CYP2C9HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163012-B2 | Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2015-10-20 | — | — | US | disclosed |
| EP-2438043-A1 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| US-20110053943-A1 | CARBAMATE AND UREA INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. | 2011-03-03 | — | — | US | disclosed |
| WO-2010141424-A1 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053943-A1 | CARBAMATE AND UREA INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885CYP3A4 126/4885CYP2D6 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.