Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Demeclocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | USP2 | O75604 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CASP7 | P55210 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demeclocycline SCHEMBL20716691 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL13085469 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL20952687 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL3252 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL3253 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL5503953 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL29355123 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL29487284 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL6549174 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL41287 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344325-A1 | LOCAL ADMINISTRATION OF DRUGS FOR THE TREATMENT OF ASTHMA | Mercator Medsystems, Inc. (US) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017040605-A1 | LOCAL ADMINISTRATION OF DRUGS FOR THE TREATMENT OF ASTHMA | MERCATOR MEDSYSTEMS, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| EP-2437596-A1 | SKIN TREATMENT COMPOSITIONS | Ex-Tek, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141711-A1 | SKIN TREATMENT COMPOSITIONS | EX-TEK, LLC (US) | 2010-12-09 | — | — | WO | disclosed |
| US-20100021530-A1 | ENHANCED TRANS-KERATIN DRUG DELIVERY | Innovation Biomedical Devices, Inc. (US) | 2010-01-28 | — | — | US | disclosed |
| WO-2010011354-A2 | ENCHANCED TRANS-KERATIN DRUG DELIVERY | Innovation Biomedical Devices, Inc. (US) | 2010-01-28 | — | — | WO | disclosed |