Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636843 | 1.00 | KDM4E (0.46) | KDM4EMAPTAPPHDAC3HDAC1 | |
| SCHEMBL1974701 | 0.92 | MAPT (0.48) | KDM4EMAPTAPPHDAC3HDAC1 | |
| SCHEMBL1974700 | 0.92 | MAPT (0.48) | KDM4EMAPTAPPHDAC3HDAC1 | |
| SCHEMBL2636189 | 0.85 | ACHE (0.48) | KDM4EMAPTAPPHDAC3HDAC1 | |
| SCHEMBL2636400 | 0.85 | ACHE (0.48) | KDM4EMAPTAPPHDAC3HDAC1 | |
| SCHEMBL13003199 | 0.83 | MAPT (0.44) | KDM4EMAPTAPPHDAC3HDAC1 | |
| SCHEMBL2637559 | 0.81 | KDM4E (0.45) | KDM4EHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2637557 | 0.81 | KDM4E (0.45) | KDM4EHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1064876 | 0.79 | KMT2A (0.51) | KDM4EMAPTAPPALDH1A1GAA | |
| SCHEMBL1064874 | 0.79 | KMT2A (0.51) | KDM4EMAPTAPPALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2437792-B1 | IMAGING OF MYELIN BASIC PROTEIN | GEN ELECTRIC (US) | 2015-10-21 | — | — | EP | disclosed |
| US-8617515-B2 | Imaging of myelin basic protein | GENERAL ELECTRIC COMPANY (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2437792-A2 | IMAGING OF MYELIN BASIC PROTEIN | General Electric Company (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141704-A2 | IMAGING OF MYELIN BASIC PROTEIN | GENERAL ELECTRIC COMPANY (US) | 2010-12-09 | — | — | WO | disclosed |