Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dapsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | CA1 | P00915 | 9/20 | 0.62 |
| ▸ | CA2 | P00918 | 9/20 | 0.62 |
| ▸ | CA9 | Q16790 | 9/20 | 0.62 |
| ▸ | CA12 | O43570 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tinidazole SCHEMBL14742527 | 0.88 | LMNA (1.00) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL21141 | 0.88 | LMNA (1.00) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL27877209 | 0.87 | LMNA (0.97) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL27640947 | 0.87 | LMNA (0.97) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL27865473 | 0.85 | LMNA (0.94) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL28888098 | 0.84 | LMNA (0.92) | LMNASMN1; SMN2CA1CA2CA9 | |
| SCHEMBL11579155 | 0.83 | LMNA (0.89) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL19149564 | 0.82 | LMNA (0.87) | LMNASMN1; SMN2CA1CA2CA9 | |
| SCHEMBL11521582 | 0.79 | LMNA (0.82) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL27731090 | 0.79 | LMNA (0.68) | LMNASMN1; SMN2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2437596-A1 | SKIN TREATMENT COMPOSITIONS | Ex-Tek, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141711-A1 | SKIN TREATMENT COMPOSITIONS | EX-TEK, LLC (US) | 2010-12-09 | — | — | WO | disclosed |