SCHEMBL2637152

SCHEMBL2637152

CCCCCCC=CC=CCCCCCCCCC(O)CCCCCCCCC=CC=CCCCCCC

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.57
GPR132 Q9UNW8 1/20 0.57
FFAR1 O14842 2/20 0.54
FFAR4 Q5NUL3 2/20 0.54
FASN P49327 1/20 0.53
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
FAAH O00519 1/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CYP3A4 P08684 1/20 0.47
GPR84 Q9NQS5 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2637149 1.00 PPARG (0.57) PPARGGPR132FFAR1FFAR4FASN
SCHEMBL31373175 0.98 FFAR1 (0.57) PPARGGPR132FFAR1FFAR4FASN
SCHEMBL6437731 0.96 PPARG (0.54) PPARGGPR132FFAR1FFAR4FASN
SCHEMBL28658939 0.93 PPARG (0.51) PPARGGPR132FFAR1FFAR4FASN
SCHEMBL28663282 0.93 PPARG (0.51) PPARGGPR132FFAR1FFAR4FASN
SCHEMBL3185051 0.91 FFAR1 (0.62) PPARGFFAR1FFAR4FAAHMEN1
SCHEMBL17744144 0.91 FFAR1 (0.62) PPARGFFAR1FFAR4FAAHMEN1
SCHEMBL2826342 0.91 FFAR1 (0.62) PPARGFFAR1FFAR4FAAHMEN1
SCHEMBL3274131 0.91 FFAR1 (0.62) PPARGFFAR1FFAR4FAAHMEN1
SCHEMBL10081525 0.91 FFAR1 (0.62) PPARGFFAR1FFAR4FAAHMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569276-B1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF ARBUTUS BIOPHARMA CORP (CA) 2021-02-24 EP disclosed
EP-2569276-B1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF ARBUTUS BIOPHARMA CORP (CA) 2021-02-24 EP disclosed
US-20200282060-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF ARBUTUS BIOPHARMA CORPORATION (CA) 2020-09-10 US disclosed
US-20200282060-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF ARBUTUS BIOPHARMA CORPORATION (CA) 2020-09-10 US disclosed
US-20170151333-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2017-06-01 US disclosed
US-20170151333-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2017-06-01 US disclosed
US-20170151333-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2017-06-01 US disclosed
US-8865675-B2 Compositions and methods for silencing apolipoprotein B PROTIVA BIOTHERAPEUTICS, INC. (CA) 2014-10-21 US disclosed
US-8865675-B2 Compositions and methods for silencing apolipoprotein B PROTIVA BIOTHERAPEUTICS, INC. (CA) 2014-10-21 US disclosed
US-8865675-B2 Compositions and methods for silencing apolipoprotein B PROTIVA BIOTHERAPEUTICS, INC. (CA) 2014-10-21 US disclosed
US-20130123338-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2013-05-16 US disclosed
US-20130123339-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B PROTIVA BIOTHERAPEUTICS INC (CA) 2013-05-16 US disclosed
US-20130123339-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B PROTIVA BIOTHERAPEUTICS INC (CA) 2013-05-16 US disclosed
US-20130123338-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2013-05-16 US disclosed
US-20130123338-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2013-05-16 US disclosed
US-20130123339-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B PROTIVA BIOTHERAPEUTICS INC (CA) 2013-05-16 US disclosed
WO-2011141703-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B PROTIVA BIOTHERAPEUTICS INC. (CA) 2011-11-17 WO disclosed
WO-2011141703-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B PROTIVA BIOTHERAPEUTICS INC. (CA) 2011-11-17 WO disclosed
WO-2011141705-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PROTIVA BIOTHERAPEUTICS, INC. (CA) 2011-11-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123338-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PLIN3, CETP, LDLR PPARG 2474/4885GPR132 2475/4885FFAR1 933/4885
US-20200282060-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PLIN3, CETP, LDLR PPARG 2474/4885GPR132 2475/4885FFAR1 933/4885
US-20130123339-A1 COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B APOB, LDLR, APOL1 PPARG 2479/4885GPR132 3717/4885FFAR1 1527/4885
US-20170151333-A1 NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF PLIN3, CETP, LDLR PPARG 2474/4885GPR132 2475/4885FFAR1 933/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.