SCHEMBL2637205

SCHEMBL2637205

CCOC(=O)C(C(=O)OCC)[C@@H](C#N)CC(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.37
HTT P42858 2/20 0.37
ALDH1A1 P00352 7/20 0.36
TSHR P16473 1/20 0.36
KMT2A Q03164 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
MEN1 O00255 2/20 0.36
GAA P10253 2/20 0.36
POLB P06746 1/20 0.34
NPSR1 Q6W5P4 2/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
NPC1 O15118 1/20 0.33
CTSK P43235 1/20 0.33
TP53 P04637 1/20 0.33
HSD17B10 Q99714 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
CYP2C9 P11712 1/20 0.32
PPID Q08752 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL261165 1.00 LMNA (0.37) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL261164 1.00 LMNA (0.37) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL260952 0.91 HTT (0.35) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL262272 0.91 HTT (0.35) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL3467830 0.91 HTT (0.35) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL263453 0.91 HTT (0.35) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL12447852 0.91 SMN1; SMN2 (0.39) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL261441 0.91 HTT (0.35) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL2920755 0.90 HTT (0.34) LMNAHTTALDH1A1TSHRKMT2A
SCHEMBL262101 0.90 HTT (0.34) LMNAHTTALDH1A1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011141923-A2 IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN LUPIN LIMITED (IN) 2011-11-17 WO claimed
WO-2023088077-A1 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. (CN) 2023-05-25 WO disclosed
WO-2011141923-A2 IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN LUPIN LIMITED (IN) 2011-11-17 WO disclosed
WO-2011141923-A2 IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN LUPIN LIMITED (IN) 2011-11-17 WO disclosed
WO-2010070593-A2 MALONATE ESTERS PFIZER IRELAND PHARMACEUTICALS (IE) 2010-06-24 WO disclosed