Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PPID | Q08752 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637205 | 1.00 | LMNA (0.37) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL261164 | 1.00 | LMNA (0.37) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL260952 | 0.91 | HTT (0.35) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL262272 | 0.91 | HTT (0.35) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL3467830 | 0.91 | HTT (0.35) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL263453 | 0.91 | HTT (0.35) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL12447852 | 0.91 | SMN1; SMN2 (0.39) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL261441 | 0.91 | HTT (0.35) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL2920755 | 0.90 | HTT (0.34) | LMNAHTTALDH1A1TSHRKMT2A | |
| SCHEMBL262101 | 0.90 | HTT (0.34) | LMNAHTTALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112939809-A | Preparation method of 1-cyano-3-methyl diethyl butylmalonate | 江苏恒沛药物科技有限公司 | 2021-06-11 | — | — | CN | claimed |
| EP-1831154-B1 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER LAMBERT CO (US) | 2010-01-13 | — | — | EP | claimed |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2009-02-12 | — | — | US | claimed |
| EP-1831154-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | Warner-Lambert Company LLC (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006000904-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | HU SHANGHUI | 2005-12-22 | — | — | US | claimed |
| CN-112939809-A | Preparation method of 1-cyano-3-methyl diethyl butylmalonate | 江苏恒沛药物科技有限公司 | 2021-06-11 | — | — | CN | disclosed |
| WO-2021105742-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2021-06-03 | — | — | WO | disclosed |
| WO-2020183376-A1 | GREENER AND ECONOMIC PROCESS FOR PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2020-09-17 | — | — | WO | disclosed |
| EP-2916832-B1 | A PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LTD (IN) | 2019-01-16 | — | — | EP | disclosed |
| US-10023885-B2 | Process for the preparation of pregabalin | HIKAL LIMITED (IN) | 2018-07-17 | — | — | US | disclosed |
| US-10023885-B2 | Process for the preparation of pregabalin | HIKAL LIMITED (IN) | 2018-07-17 | — | — | US | disclosed |
| US-20150344919-A1 | PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2015-12-03 | — | — | US | disclosed |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2009-02-12 | — | — | US | disclosed |
| JP-2009022272-A | PRODUCTION OF PREGABALIN AND RELATED COMPOUND | WARNER-LAMBERT CO LLC | 2009-02-05 | — | — | JP | disclosed |
| US-20080311635-A1 | PROCESS FOR THE PREPARATION OF (S)(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | DIPHARMA FRANCIS S.R.L. (IT) | 2008-12-18 | — | — | US | disclosed |
| WO-2008062460-A2 | CRYSTALLINE FORMS OF PREGABALIN | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |
| EP-1831154-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | Warner-Lambert Company LLC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006000904-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | HU SHANGHUI | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080311635-A1 | PROCESS FOR THE PREPARATION OF (S)(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | ADH5, ALDH7A1, ADH1C | LMNA 2332/4885HTT 4536/4885ALDH1A1 106/4885 |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | LMNA 1702/4885HTT 3176/4885ALDH1A1 786/4885 |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | GABRE, GABRG1, GABRA6 | LMNA 1702/4885HTT 3176/4885ALDH1A1 786/4885 |
| US-10023885-B2 | Process for the preparation of pregabalin | CHRNA6, CHRNA9, ADH5 | LMNA 1468/4885HTT 2484/4885ALDH1A1 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.