Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 4/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | PRKACA | P17612 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | PRKX | P51817 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637232 | 0.82 | AXL (0.45) | AXLDYRK1BRPS6KA5GRM8GRM4 | |
| SCHEMBL19471801 | 0.76 | CCNB2 (0.40) | AXLDYRK1BRPS6KA5GRM8GRM4 | |
| SCHEMBL858184 | 0.76 | AXL (0.48) | AXLDYRK1BRPS6KA5GRM8GRM4 | |
| SCHEMBL17435055 | 0.74 | AXL (0.37) | AXLDYRK1BRPS6KA5GRM8GRM4 | |
| SCHEMBL858300 | 0.74 | AXL (0.44) | AXLDYRK1BRPS6KA5GRM8GRM4 | |
| SCHEMBL857039 | 0.72 | MAPT (0.49) | AXLGRM8GRM4MAPTGPR84 | |
| SCHEMBL21872984 | 0.71 | CDC7 (0.41) | AXLDYRK1BRPS6KA5GRM8GRM4 | |
| SCHEMBL1267952 | 0.71 | AXL (0.48) | AXLGRM8GRM4MAPTGPR84 | |
| SCHEMBL1359136 | 0.71 | MET (0.43) | MAP4K4CLK2CDK5DYRK1ACLK4 | |
| SCHEMBL1358648 | 0.70 | ITK (0.46) | MAPTMAP4K4CLK2CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569314-A1 | FUSED BICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, LLC (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143645-A1 | FUSED BICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, LLC (US) | 2011-11-17 | — | — | WO | disclosed |