Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 8/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.38 |
| ▸ | PIM1 | P11309 | 6/20 | 0.38 |
| ▸ | PRKACA | P17612 | 6/20 | 0.38 |
| ▸ | GSK3B | P49841 | 6/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.37 |
| ▸ | CDK8 | P49336 | 4/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.37 |
| ▸ | CLK2 | P49760 | 4/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.37 |
| ▸ | CDK9 | P50750 | 4/20 | 0.37 |
| ▸ | PRKX | P51817 | 4/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637371 | 0.82 | AXL (0.48) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL17435055 | 0.80 | AXL (0.37) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL858184 | 0.75 | AXL (0.48) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL3701118 | 0.73 | GRM8 (0.40) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL413222 | 0.72 | MET (0.40) | PIM1PRKACAGSK3BHIPK2ROCK2 | |
| SCHEMBL857047 | 0.71 | MAPT (0.46) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL858300 | 0.71 | AXL (0.44) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL19471801 | 0.71 | CCNB2 (0.40) | AXLCDC7CLK4MAP4K4PIM1 | |
| SCHEMBL1359136 | 0.70 | MET (0.43) | CLK4MAP4K4HIPK2ROCK2CDK2 | |
| SCHEMBL3701115 | 0.70 | CAMKK2 (0.43) | AXLGRM8GRM4LRRK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2710003-A1 | FUSED BICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, LLC (US) | 2014-03-26 | — | — | EP | disclosed |
| EP-2569314-A1 | FUSED BICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, LLC (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2012158658-A1 | FUSED BICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, LLC (US) | 2012-11-22 | — | — | WO | disclosed |
| WO-2011143645-A1 | FUSED BICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, LLC (US) | 2011-11-17 | — | — | WO | disclosed |