Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Halcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.73 |
| ▸ | PGR | P06401 | 5/20 | 0.73 |
| ▸ | AR | P10275 | 3/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.66 |
| ▸ | CHUK | O15111 | 1/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halcinonide SCHEMBL28142872 | 0.97 | CYP3A4 (0.76) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL9810174 | 0.93 | CYP3A4 (0.68) | CYP3A4NR3C1PGRARUSP2 | |
| Triamcinolone Acetonide SCHEMBL28103100 | 0.90 | CYP3A4 (0.87) | CYP3A4NR3C1PGRARHIF1A | |
| Halcinonide SCHEMBL677232 | 0.87 | CYP3A4 (0.71) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL24015431 | 0.85 | NR3C1 (1.00) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL7861670 | 0.85 | NR3C1 (1.00) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL5188866 | 0.85 | NR3C1 (1.00) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL5489567 | 0.85 | NR3C1 (1.00) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL13026159 | 0.85 | NR3C1 (1.00) | CYP3A4NR3C1PGRARUSP2 | |
| Halcinonide SCHEMBL10019829 | 0.85 | NR3C1 (1.00) | CYP3A4NR3C1PGRARUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107208054-A | Induced hepatocytes and uses thereof | 艾克塞利瑞提德生物技术公司 | 2017-09-26 | — | — | CN | disclosed |
| US-20120125325-A1 | THE USE OF AMLEXANOX IN THE THERAPY OF NEUTROPHIL-DRIVEN DISEASES | BIOCOPEA, LTD. (GB) | 2012-05-24 | — | — | US | disclosed |
| EP-2437741-A1 | THE USE OF AMLEXANOX IN THE THERAPY OF NEUTROPHIL-DRIVEN DISEASES | Biocopea Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139985-A1 | THE USE OF AMLEXANOX IN THE THERAPY OF NEUTROPHIL-DRIVEN DISEASES | BIOCOPEA LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |