Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Halcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.68 |
| ▸ | PGR | P06401 | 7/20 | 0.68 |
| ▸ | AR | P10275 | 6/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halcinonide SCHEMBL2637394 | 0.93 | CYP3A4 (0.73) | CYP3A4PGRARNR3C1USP2 | |
| Halcinonide SCHEMBL28142872 | 0.90 | CYP3A4 (0.76) | CYP3A4PGRARNR3C1USP2 | |
| Fluocinolone Acetonide SCHEMBL5501859 | 0.89 | HIF1A (0.77) | CYP3A4PGRARNR3C1HIF1A | |
| Fluocinonide SCHEMBL22463815 | 0.88 | NR3C1 (0.75) | CYP3A4PGRARNR3C1USP2 | |
| Halobetasol Propionate SCHEMBL28198190 | 0.88 | PGR (0.67) | CYP3A4PGRARNR3C1USP2 | |
| Fluocinolone Acetonide SCHEMBL8451856 | 0.85 | NR3C1 (0.60) | CYP3A4PGRARNR3C1USP2 | |
| Fluocinonide SCHEMBL28122375 | 0.84 | HIF1A (0.75) | CYP3A4PGRARNR3C1USP2 | |
| Fluocinonide SCHEMBL3475945 | 0.84 | HIF1A (0.75) | CYP3A4PGRARNR3C1USP2 | |
| Triamcinolone Acetonide SCHEMBL28103100 | 0.83 | CYP3A4 (0.87) | CYP3A4PGRARNR3C1HIF1A | |
| Halcinonide SCHEMBL24015431 | 0.83 | NR3C1 (1.00) | CYP3A4PGRARNR3C1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017567-A | Steroid antiinflammatory | SCHERING CORPORATION (US) | 1991-05-21 | — | — | US | claimed |
| US-4885293-A | CARBOXYALKYL DIPEPTIDES | SCHERING CORPORATION (US) | 1989-12-05 | — | — | US | claimed |
| US-4783444-A | SUBSTITUTED DIPEPTIDES | SCHERING CORPORATION (US) | 1988-11-08 | — | — | US | claimed |