Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637207 | 0.88 | CNR2 (0.45) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL2637655 | 0.87 | NPC1 (0.42) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL2637506 | 0.85 | MEN1 (0.40) | TSHRMEN1KMT2A | |
| SCHEMBL2637448 | 0.84 | NPC1 (0.46) | POLBMEN1KMT2A | |
| SCHEMBL2637493 | 0.83 | NHERF1 (0.46) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL2637430 | 0.83 | NPC1 (0.48) | MAPTPOLBMEN1KMT2A | |
| SCHEMBL2637260 | 0.82 | CNR2 (0.50) | MEN1KMT2AKCNMA1 | |
| SCHEMBL2637188 | 0.81 | MGAM (0.50) | MAPTMEN1KMT2AKCNMA1LMNA | |
| SCHEMBL2637403 | 0.80 | MEN1 (0.47) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL2637450 | 0.80 | MEN1 (0.38) | POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |