Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.47 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637430 | 0.84 | NPC1 (0.48) | MEN1KMT2APABPC1MAPTNPC1 | |
| SCHEMBL2637260 | 0.83 | CNR2 (0.50) | MEN1KMT2ANPC1HDAC6ALDH1A1 | |
| SCHEMBL2638320 | 0.82 | DHPS (0.46) | MEN1KMT2ANPC1 | |
| SCHEMBL2637533 | 0.80 | MAPT (0.50) | MEN1KMT2AMAPTLMNAPOLB | |
| SCHEMBL2637506 | 0.80 | MEN1 (0.40) | MEN1KMT2ANPC1CYP3A4 | |
| SCHEMBL2637188 | 0.80 | MGAM (0.50) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL2637207 | 0.80 | CNR2 (0.45) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL2637531 | 0.79 | NPC1 (0.44) | MEN1KMT2ANPC1CYP3A4SMN1; SMN2 | |
| SCHEMBL2637655 | 0.79 | NPC1 (0.42) | MEN1KMT2AMAPTNPC1NPSR1 | |
| SCHEMBL2637827 | 0.79 | NPC1 (0.54) | MEN1KMT2AMAPTNPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |