Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | SELE | P16581 | 2/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12841233 | 0.93 | OPRK1 (0.36) | OPRK1CHEK1CHEK2KDM4ETDP1 | |
| SCHEMBL15029754 | 0.93 | OPRK1 (0.36) | OPRK1CHEK1CHEK2KDM4ETDP1 | |
| SCHEMBL1534231 | 0.90 | OPRK1 (0.35) | OPRK1CHEK1KDM4ETDP1BACE1 | |
| SCHEMBL1534182 | 0.90 | OPRK1 (0.35) | OPRK1CHEK1KDM4ETDP1BACE1 | |
| SCHEMBL30662548 | 0.90 | OPRK1 (0.35) | OPRK1CHEK1KDM4ETDP1BACE1 | |
| SCHEMBL12850782 | 0.90 | OPRK1 (0.35) | OPRK1CHEK1KDM4ETDP1BACE1 | |
| SCHEMBL16975985 | 0.90 | OPRK1 (0.36) | OPRK1CHEK1CHEK2KDM4ETDP1 | |
| SCHEMBL11963323 | 0.90 | SLC22A12 (0.37) | OPRK1CHEK1CHEK2KDM4ETDP1 | |
| SCHEMBL18499305 | 0.90 | OPRK1 (0.36) | OPRK1CHEK1CHEK2KDM4ETDP1 | |
| SCHEMBL15923274 | 0.90 | SLC22A12 (0.37) | OPRK1CHEK1CHEK2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846731-B2 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents | FERROKIN BIOSCIENCES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-8829197-B2 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents | FERROKIN BIOSCIENCES, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8710087-B2 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents | FERROKIN BIOSCIENCES, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20120270911-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120202857-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20110160257-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2011-06-30 | — | — | US | disclosed |
| US-20100137383-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| WO-2010009120-A2 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160257-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | OPRK1 1535/4885CHEK1 4261/4885CHEK2 4363/4885 |
| US-20120202857-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | OPRK1 1704/4885CHEK1 4176/4885CHEK2 4248/4885 |
| US-20120270911-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | OPRK1 1704/4885CHEK1 4176/4885CHEK2 4248/4885 |
| US-20100137383-A1 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, SLC39A11 | OPRK1 1535/4885CHEK1 4261/4885CHEK2 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.