⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26378518 | 0.79 | PRKCA (0.31) | — | |
| SCHEMBL24069465 | 0.79 | USP2 (0.30) | — | |
| SCHEMBL18135528 | 0.77 | — | — | |
| SCHEMBL197122 | 0.73 | — | — | |
| SCHEMBL8721546 | 0.73 | — | — | |
| SCHEMBL13542888 | 0.73 | — | — | |
| SCHEMBL197121 | 0.73 | — | — | |
| SCHEMBL15336525 | 0.73 | — | — | |
| SCHEMBL30207652 | 0.72 | LMNA (0.30) | — | |
| Hydrochloric Acid SCHEMBL9807456 | 0.71 | PTGS1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312591-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2023-10-05 | — | — | US | disclosed |
| US-20230131402-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2023-04-27 | — | — | US | disclosed |