Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638918 | 0.91 | HDAC1 (0.51) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL2638247 | 0.88 | HDAC1 (0.47) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL2638427 | 0.87 | HDAC1 (0.46) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL2638675 | 0.85 | HDAC1 (0.46) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL2637850 | 0.85 | HDAC1 (0.47) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL2637851 | 0.84 | HDAC1 (0.53) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL2639027 | 0.84 | CAMK2D (0.54) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL2637961 | 0.84 | HDAC1 (0.42) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL2638221 | 0.83 | HDAC1 (0.47) | HDAC1JAK2HDAC3HDAC2HDAC11 | |
| SCHEMBL3133124 | 0.83 | HDAC1 (0.43) | HDAC1HDAC3HDAC2HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011528039-A | — | — | 2011-11-10 | — | — | JP | claimed |
| WO-2010009139-A2 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | claimed |
| WO-2010009139-A2 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |