Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.43 |
| ▸ | ABL1 | P00519 | 9/20 | 0.43 |
| ▸ | BCR | P11274 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637961 | 0.88 | HDAC1 (0.42) | HDAC1ABL1HDAC3HDAC2HDAC11 | |
| SCHEMBL2637833 | 0.86 | HDAC2 (0.46) | HDAC1ABL1BCRHDAC3HDAC2 | |
| SCHEMBL2637925 | 0.86 | KCNH2 (0.48) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL2638726 | 0.83 | HDAC1 (0.61) | HDAC1ABL1HDAC3HDAC2HDAC11 | |
| SCHEMBL2638918 | 0.81 | HDAC1 (0.51) | HDAC1ABL1BCRHDAC3HDAC2 | |
| SCHEMBL274399 | 0.79 | CDK2 (0.53) | HDAC1ABL1BCR | |
| SCHEMBL2638200 | 0.77 | HDAC1 (0.39) | HDAC1ABL1HDAC3HDAC2HDAC11 | |
| SCHEMBL699812 | 0.75 | HDAC1 (0.64) | HDAC1ABL1BCR | |
| SCHEMBL2637841 | 0.74 | HDAC2 (0.43) | HDAC1HDAC3HDAC2 | |
| SCHEMBL2638901 | 0.74 | HDAC2 (0.43) | HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009139-A2 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |