Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638571 | 0.98 | EPHX2 (0.59) | EPHX2EPHX1SIGMAR1TSHRALDH1A1 | |
| SCHEMBL3928986 | 0.83 | EPHX2 (0.61) | EPHX2EPHX1 | |
| SCHEMBL5157950 | 0.83 | EPHX1 (0.61) | EPHX2EPHX1TSHRKMT2A | |
| SCHEMBL3920461 | 0.82 | EPHX2 (0.55) | EPHX2EPHX1TSHRALDH1A1MEN1 | |
| SCHEMBL3375706 | 0.81 | PBK (0.41) | EPHX2EPHX1SIGMAR1TSHRMEN1 | |
| SCHEMBL3375700 | 0.80 | SIGMAR1 (0.41) | EPHX2EPHX1SIGMAR1TSHRHSD11B1 | |
| SCHEMBL3375841 | 0.80 | EPHX1 (0.42) | EPHX2EPHX1SIGMAR1TSHRMEN1 | |
| SCHEMBL3375837 | 0.79 | SIGMAR1 (0.43) | EPHX2EPHX1SIGMAR1TSHRMEN1 | |
| SCHEMBL2638369 | 0.78 | EPHX2 (0.41) | EPHX2EPHX1SIGMAR1TSHRHSD11B1 | |
| SCHEMBL10138566 | 0.77 | EPHX2 (0.44) | EPHX2EPHX1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011529057-A | — | — | 2011-12-01 | — | — | JP | claimed |
| WO-2010011570-A1 | ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2010-01-28 | — | — | WO | claimed |