Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911337 | 0.89 | TAAR1 (0.63) | TAAR1CHRM2CHRM1CHRM3ATM | |
| SCHEMBL13253641 | 0.84 | MEN1 (0.47) | TAAR1CHRM2CHRM1CHRM3ATM | |
| SCHEMBL2906778 | 0.77 | TAAR1 (0.63) | TAAR1CHRM2CHRM1CHRM3ATM | |
| SCHEMBL3210964 | 0.77 | MTNR1A (0.48) | SIGMAR1MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL9490025 | 0.76 | TP53 (0.52) | TAAR1TP53CYP1A2MEN1KMT2A | |
| SCHEMBL3052902 | 0.74 | TAAR1 (0.59) | TAAR1CHRM2CHRM1CHRM3ATM | |
| SCHEMBL166894 | 0.73 | TP53 (0.61) | SIGMAR1MAPTTP53CYP1A2MAPK1 | |
| SCHEMBL21257474 | 0.73 | MAPT (0.50) | TAAR1SIGMAR1MAPTCYP1A2ALOX15 | |
| SCHEMBL7976598 | 0.73 | SIGMAR1 (0.48) | SIGMAR1MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL8441355 | 0.72 | KDM4E (0.54) | MAPTTP53CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512842-B1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS INC (US) | 2024-01-17 | — | — | EP | disclosed |
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |