Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 4/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26393411 | 0.88 | GSK3B (0.45) | JAK2JAK1TYK2JAK3FADS1 | |
| SCHEMBL26393370 | 0.88 | GSK3B (0.53) | JAK2JAK1TYK2JAK3GSK3B | |
| SCHEMBL26393638 | 0.86 | TRPA1 (0.43) | JAK2JAK1TYK2JAK3FADS1 | |
| SCHEMBL26393947 | 0.86 | JAK2 (0.61) | JAK2JAK1TYK2JAK3FADS1 | |
| SCHEMBL26393914 | 0.85 | FADS1 (0.42) | JAK2JAK1TYK2JAK3FADS1 | |
| SCHEMBL26394024 | 0.81 | GSK3B (0.44) | JAK2JAK1TYK2JAK3FADS1 | |
| SCHEMBL26393862 | 0.81 | GSK3B (0.45) | JAK2JAK1TYK2JAK3GSK3B | |
| SCHEMBL26396626 | 0.80 | HDAC6 (0.48) | JAK2JAK1TYK2JAK3FADS1 | |
| SCHEMBL26397024 | 0.79 | LRRK2 (0.41) | JAK2JAK1TYK2JAK3GSK3B | |
| SCHEMBL26393980 | 0.76 | GSK3B (0.57) | JAK2GSK3BHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |