Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272613 | 0.87 | PDCD1 (0.38) | POLBHTTALDH1A1RAB9AKMT2A | |
| SCHEMBL2638612 | 0.86 | KDM4E (0.50) | KDM4EPOLBHTTALDH1A1MAPT | |
| SCHEMBL2639950 | 0.83 | CHRM2 (0.37) | KDM4EPOLBALDH1A1RAB9AKMT2A | |
| SCHEMBL6022003 | 0.83 | KDM4E (0.50) | KDM4EPOLBHTTALDH1A1MAPT | |
| SCHEMBL4694436 | 0.80 | NPC1 (0.38) | HTTALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL4693976 | 0.78 | NPC1 (0.36) | HTTALDH1A1RAB9AKMT2AHPGD | |
| SCHEMBL6022004 | 0.78 | POLB (0.43) | KDM4EPOLBALDH1A1KMT2A | |
| SCHEMBL1304570 | 0.76 | CHRM3 (0.53) | — | |
| SCHEMBL1304566 | 0.76 | CHRM3 (0.53) | — | |
| SCHEMBL5276784 | 0.73 | EPHX2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4837653-B2 | — | — | 2011-12-14 | — | — | JP | claimed |
| JP-2008532922-A | — | — | 2008-08-21 | — | — | JP | claimed |
| EP-1723114-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | claimed |
| WO-2005087738-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | claimed |
| EP-1723114-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087738-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |