Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638612 | 0.87 | KDM4E (0.50) | KDM4EPOLBHTTATML3MBTL1 | |
| SCHEMBL2639463 | 0.83 | KDM4E (0.46) | KDM4EPOLBHTTATML3MBTL1 | |
| SCHEMBL5501520 | 0.83 | CHRM2 (0.43) | KDM4ERAB9AALDH1A1AKT1BCHE | |
| SCHEMBL4691194 | 0.82 | DRD4 (0.38) | KDM4ERAB9AALDH1A1MAPTAKT1 | |
| SCHEMBL5412081 | 0.81 | CD274 (0.44) | L3MBTL1RAB9AAKT1SMN1; SMN2 | |
| SCHEMBL4694768 | 0.81 | HDAC1 (0.36) | BCHESMN1; SMN2ACHE | |
| SCHEMBL4695736 | 0.81 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL4695744 | 0.81 | HDAC1 (0.37) | KDM4EPOLBRAB9AALDH1A1MAPT | |
| SCHEMBL4695511 | 0.80 | PDCD1 (0.34) | HTTSMN1; SMN2 | |
| SCHEMBL4694755 | 0.79 | OPRK1 (0.32) | KDM4ERAB9AALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723114-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087738-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |