Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638612 | 0.92 | KDM4E (0.50) | POLBKDM4EALDH1A1ACHEBCHE | |
| SCHEMBL2639688 | 0.90 | POLB (0.44) | POLBKDM4EALDH1A1GAAACHE | |
| SCHEMBL4695739 | 0.82 | AKR1C3 (0.40) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4695176 | 0.81 | POLB (0.37) | POLBKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL4695551 | 0.80 | CNR2 (0.40) | POLBKDM4EMEN1KMT2ALMNA | |
| SCHEMBL6022071 | 0.80 | GAA (0.46) | POLBKDM4EALDH1A1GAALTA4H | |
| SCHEMBL4691773 | 0.79 | KDM4E (0.41) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6027475 | 0.79 | TRPV1 (0.37) | POLBKDM4ELMNAGAALTA4H | |
| SCHEMBL4693546 | 0.79 | POLB (0.40) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6022003 | 0.78 | KDM4E (0.50) | POLBKDM4EALDH1A1ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723114-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087738-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |