Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064429 | 0.90 | KCNA5 (0.53) | KCNA5KCNH2IDO1MAPK1KDM4E | |
| SCHEMBL2639092 | 0.80 | IDO1 (0.45) | KCNA5KCNH2IDO1MAPK1KDM4E | |
| SCHEMBL2639285 | 0.78 | KCNA5 (0.46) | KCNA5KCNH2IDO1MAPK1KDM4E | |
| SCHEMBL2639760 | 0.77 | IDO1 (0.43) | KCNA5KCNH2IDO1MAPK1KDM4E | |
| SCHEMBL3625695 | 0.76 | KCNA5 (0.62) | KCNA5KCNH2ALDH1A1KMT2AGRIA2 | |
| SCHEMBL2640067 | 0.76 | CLK1 (0.44) | KCNA5KCNH2IDO1MAPK1KDM4E | |
| SCHEMBL2640045 | 0.72 | ALDH1A1 (0.58) | KCNA5KCNH2IDO1MAPK1KDM4E | |
| SCHEMBL2640082 | 0.72 | KCNA5 (0.74) | KCNA5KCNH2MAPK1KDM4EALDH1A1 | |
| SCHEMBL2169067 | 0.72 | KCNA5 (0.50) | KCNA5KCNH2KDM4E | |
| SCHEMBL2639657 | 0.68 | IDO1 (0.43) | IDO1MAPK1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4794445-B2 | — | — | 2011-10-19 | — | — | JP | claimed |
| EP-1667973-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | claimed |
| WO-2005030792-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | claimed |
| EP-1667973-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030792-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |