Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.44 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892387 | 0.79 | PARP10 (0.50) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL23774 | 0.72 | PARP1 (0.71) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL689841 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL1906838 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL27703657 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL29102653 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL11512422 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL7508927 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL15328883 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 | |
| Terephthalamide SCHEMBL1087289 | 0.69 | PARP1 (0.67) | PARP10PARP4PARP1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |