⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26404619 | 0.73 | — | — | |
| SCHEMBL20126490 | 0.72 | POLB (0.34) | — | |
| SCHEMBL1431720 | 0.70 | TDP1 (0.38) | — | |
| SCHEMBL737459 | 0.70 | TDP1 (0.38) | — | |
| SCHEMBL2106917 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL14909783 | 0.65 | — | — | |
| SCHEMBL8385453 | 0.65 | DPP4 (0.30) | — | |
| SCHEMBL14909785 | 0.65 | — | — | |
| SCHEMBL17474205 | 0.62 | POLB (0.34) | — | |
| SCHEMBL10471873 | 0.62 | ALDH1A1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780826-B2 | Bisamide sarcomere activating compounds and uses thereof | AMGEN INC. (US) | 2023-10-10 | — | — | US | disclosed |