Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 13/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 13/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506070 | 0.87 | LPL (0.39) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL22655335 | 0.87 | LIPG (0.43) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL505914 | 0.85 | LPL (0.41) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL506126 | 0.85 | LPL (0.36) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL505959 | 0.81 | LPL (0.34) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL12492834 | 0.81 | LPL (0.42) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL21916888 | 0.79 | LPL (0.37) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL506825 | 0.79 | LPL (0.39) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL506413 | 0.79 | ESR2 (0.43) | LPLLIPGFFAR1CA1CA2 | |
| SCHEMBL505949 | 0.78 | LPL (0.36) | LPLLIPGFFAR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3713927-B1 | PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS | NOVARTIS AG (CH) | 2021-12-15 | — | — | EP | disclosed |
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2021-11-02 | — | — | US | disclosed |
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2021-11-02 | — | — | US | disclosed |
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2020-11-19 | — | — | US | disclosed |
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2020-11-19 | — | — | US | disclosed |
| CN-111433195-A | Pyridone derivatives and their use as selective A L K-2 inhibitors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | disclosed |
| US-9630956-B2 | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-04-25 | — | — | US | disclosed |
| EP-2569313-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143426-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | ALK, ACVR2B, ACVR1B | LPL 2799/4885LIPG 2497/4885FFAR1 1341/4885 |
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | ALK, ACVR2B, ACVR1B | LPL 2799/4885LIPG 2497/4885FFAR1 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.